PDRN & Retinol Shot Ampoule
Reviewed by SerumTruth Editorial · Updated July 2026
An interesting skin-booster ampoule that puts a purity-graded PDRN complex front and center and pairs it with a spicule-delivered retinol gentle enough for retinol-shy skin. Neither active carries an independently disclosed percentage, so you are trusting the brand's formulation rather than checking a number, and the packaging is not fully suited to either fragile ingredient. Reasonable value for a two-in-one regenerating and retinizing ampoule at this price, best for someone easing into retinol who wants the PDRN story as a bonus.
- Evidence26 / 30
Strength of the research behind the key actives
- Growth Factors (TNS): moderate evidence
- Retinol: strong evidence
The average of the key actives’ evidence grades.
- Potency20 / 25
Dosed at studied levels, not fairy-dusted
- Growth Factors (TNS): dosed at a studied level
- Retinol: present, but below a studied dose
How strongly the actives are dosed, led by the strongest, not how many there are.
- Delivery & stability16 / 20
Delivery tech + packaging that protects fragile actives
- Delivery: encapsulated (protects and time-releases the active)
- Packaging: tinted glass
- Air- or light-sensitive actives (Growth Factors (TNS), Retinol), so packaging is scored.
Delivery tech plus packaging, and packaging only counts when actives are fragile.
- Formulation3 / 10
Disclosure, active breadth, and ingredient generation
- 0 of 2 actives disclose a concentration
- 2 key actives (breadth credit caps at 3)
- Current-generation or synergistic: Growth Factors (TNS)
Disclosure, active breadth, and current-generation or synergistic actives.
- Value15 / 15
What a month of use costs vs. the category
- About $7 per month to use
- $22 for 30 ml, used about once a day (about 0.3 ml each time), so a bottle lasts about 3.3 months
- Frequency is set by Retinol, which is used no more than 7x a week, so a bottle stretches further
What a month of use costs: full marks at $6 a month or less, the floor at $60 a month or more.
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What’s inside
| Active | Disclosed | Dose |
|---|---|---|
| Growth Factors (TNS) | n/a | Studied |
| Retinol | n/a | Light |
Built around Sodium DNA, the INCI name for PDRN (polydeoxyribonucleotide, here from salmon and brand-stated at 99% purity), paired with retinol coated onto hydrolyzed sponge (marine spicule) particles for a slower, gentler release, plus centella asiatica, ceramide NP and hydrolyzed sodium hyaluronate. There is no dedicated PDRN entry in this catalog, so it is scored against growth-factors, the closest analog: both are proprietary complexes credited to cell-signalling for the appearance of firmer, more resilient-looking skin rather than a single named molecule, and both are dosed at whatever level the finished, brand-tested serum contains rather than an independently disclosed percentage. The retinol itself is not quantified and sits at the very end of the ingredient list, so treat it as a mild, slow-release addition rather than a measured retinol strength. PDRN and retinol are both light-sensitive, and a dropper is a middling choice for either; the tinted glass helps some but is not the airless, opaque setup this pairing deserves.
How it’s delivered
Air- and light-sensitive actives (vitamin C, copper peptides) lose potency fast in the wrong packaging, so delivery and the bottle are scored, not just what’s on the label.
The actives, explained
Cosmetic information for general education, not medical advice. The SerumProof score reflects our reading of publicly available research and formulation disclosures. See how scoring works.