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iS Clinical

Active Serum

$155·30 ml·~$47/mo to use

Reviewed by SerumTruth Editorial · Price and formula checked July 2026

A capable, well-evidenced acid-and-brightening serum aimed at texture and tone, wrapped in a clinical-brand price. The active levels are undisclosed and the arbutin is more garnish than dose. It works, but you are paying a steep premium over cheaper acids that do the core job.

Watch-outs
  • 1 listed active is fairy-dusted below the 1% line
  • No active concentrations are disclosed
  • Costly to use, about $47 a month
SerumProof score66 / 100
  • Evidence24 / 30

    Strength of the research behind the key actives

    • Glycolic Acid: strong evidence
    • Salicylic Acid: moderate evidence
    • Alpha Arbutin: moderate evidence

    The average of the key actives’ evidence grades.

  • Potency19 / 25

    Dosed at studied levels, not fairy-dusted

    • Glycolic Acid: dosed at a studied level
    • Salicylic Acid: dosed at a studied level
    • Alpha Arbutin: below the 1% line, treated as fairy-dusted

    How strongly the actives are dosed, led by the strongest, not how many there are.

  • Delivery & stability14 / 20

    Delivery tech + packaging that protects fragile actives

    • Delivery: standard
    • Packaging: tinted glass
    • No fragile actives here, so packaging barely moves the score.

    Delivery tech plus packaging, and packaging only counts when actives are fragile.

  • Formulation3 / 10

    Disclosure, active breadth, and ingredient generation

    • 0 of 3 actives disclose a concentration
    • 3 key actives (breadth credit caps at 3)
    • Current-generation or synergistic: Alpha Arbutin

    Disclosure, active breadth, and current-generation or synergistic actives.

  • Value6 / 15

    What a month of use costs vs. the category

    • About $47 per month to use
    • $155 for 30 ml, used about once a day (about 0.3 ml each time), so a bottle lasts about 3.3 months
    • Frequency is set by Glycolic Acid, which is used no more than 7x a week, so a bottle stretches further

    What a month of use costs: full marks at $6 a month or less, the floor at $60 a month or more.

Tap any row to see how its score was built.

Ranks #24 of 26 exfoliating acids serums we have scored.

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What’s inside

ActiveDisclosedDose
Glycolic Acidn/aStudied
Salicylic Acidn/aStudied
Alpha Arbutinn/aBelow 1% line

A multi-tasking treatment serum combining sugarcane-derived glycolic acid, salicylic acid and arbutin for surface renewal and the appearance of a clearer, more even tone, in a frosted-glass pump. iS Clinical does not disclose the individual percentages, and the arbutin sits low on the list as a supporting brightener rather than a headline dose. It is potent and best introduced slowly.

How it’s delivered

DeliveryStandardPackagingTinted glass

Air- and light-sensitive actives (vitamin C, copper peptides) lose potency fast in the wrong packaging, so delivery and the bottle are scored, not just what’s on the label.

The actives, explained

What the research says

Topical glycolic acid was linked to a smoother, more evenly toned looking appearance in sun exposed skin in a small clinical study.

Improving the cosmetic appearance of photoaged skin with glycolic acid. Journal of the American Academy of Dermatology, 1997. PubMed ↗

A 1.5% salicylic acid cream was linked to visibly clearer looking, blemish-prone skin after 4 weeks in an open clinical study.

Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline-controlled clinical study. Skin Research and Technology, 2013. PubMed ↗

A study of the active, not this exact product. What matters for the score is whether this serum uses it at a comparable dose.

Higher-scoring alternatives

Same category, better SerumProof score. Worth a look before you buy.

Revision history
  1. July 11, 2026
    Price and formula rechecked
  2. July 10, 2026
    Review published

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Cosmetic information for general education, not medical advice. The SerumProof score reflects our reading of publicly available research and formulation disclosures. See how scoring works.