Advanced Night Repair Serum Synchronized Multi-Recovery Complex
Reviewed by SerumTruth Editorial · Price and formula checked July 2026
The category flagship, and the ferment science behind it is more than a marketing story. Nothing on the label is disclosed at a percentage, though, so you are trusting Estée Lauder’s own studies rather than anything you can check against the INCI. Buy it for the ferment and the brand equity, not for an auditable dose.
- No active concentrations are disclosed
- Costly to use, about $53 a month
- Evidence18 / 30
Strength of the research behind the key actives
- Bifida Ferment Lysate: moderate evidence
- Hyaluronic Acid: moderate evidence
- Palmitoyl Tripeptide-5: limited evidence
The average of the key actives’ evidence grades.
- Potency20 / 25
Dosed at studied levels, not fairy-dusted
- Bifida Ferment Lysate: dosed at a studied level
- Hyaluronic Acid: dosed at a studied level
- Palmitoyl Tripeptide-5: present, but below a studied dose
How strongly the actives are dosed, led by the strongest, not how many there are.
- Delivery & stability14 / 20
Delivery tech + packaging that protects fragile actives
- Delivery: standard
- Packaging: tinted glass
- No fragile actives here, so packaging barely moves the score.
Delivery tech plus packaging, and packaging only counts when actives are fragile.
- Formulation3 / 10
Disclosure, active breadth, and ingredient generation
- 0 of 3 actives disclose a concentration
- 3 key actives (breadth credit caps at 3)
- Current-generation or synergistic: Bifida Ferment Lysate
Disclosure, active breadth, and current-generation or synergistic actives.
- Value5 / 15
What a month of use costs vs. the category
- About $53 per month to use
- $88 for 30 ml, used about twice a day (about 0.3 ml each time), so a bottle lasts about 1.7 months
What a month of use costs: full marks at $6 a month or less, the floor at $60 a month or more.
Tap any row to see how its score was built.
Ranks #78 of 84 hydration & barrier serums we have scored.
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What’s inside
| Active | Disclosed | Dose |
|---|---|---|
| Bifida Ferment Lysate | n/a | Studied |
| Hyaluronic Acid | n/a | Studied |
| Palmitoyl Tripeptide-5 | n/a | Light |
Second on the ingredient list behind water is Bifida Ferment Lysate, paired with sodium hyaluronate and Estée Lauder’s own Tripeptide-32 (branded the ChronoLux CB repair complex, not a licensed peptide with a published studied range). None of the actives here carry a disclosed percentage. It ships in an amber tinted-glass dropper bottle, which suits a fermented, colour-shifting formula but is not airless, so oxidation starts the day it is opened.
How it’s delivered
Air- and light-sensitive actives (vitamin C, copper peptides) lose potency fast in the wrong packaging, so delivery and the bottle are scored, not just what’s on the label.
The actives, explained
What the research says
Lab testing on skin cells found bifida ferment lysate boosted skin barrier related genes and showed antioxidant activity.
The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro. Journal of Cosmetic Dermatology, 2023. PubMed ↗
A multicenter study linked a topical hyaluronic acid serum with better looking hydration, tone, and texture over several follow up visits.
Multicenter evaluation of a topical hyaluronic acid serum. Journal of Cosmetic Dermatology, 2022. PubMed ↗
A study of the active, not this exact product. What matters for the score is whether this serum uses it at a comparable dose.
Higher-scoring alternatives
Same category, better SerumProof score. Worth a look before you buy.
Revision history
- July 11, 2026Price and formula rechecked
- July 10, 2026Review published
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Cosmetic information for general education, not medical advice. The SerumProof score reflects our reading of publicly available research and formulation disclosures. See how scoring works.