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SkinMedica

TNS Advanced+ Serum

$295·28.4 ml·~$187/mo to use

Reviewed by SerumTruth Editorial · Updated July 2026

The packaging is excellent and the price matches it. The growth-factor evidence is real but modest and largely brand-led, and on proven actives per dollar it is very hard to justify over options a tenth of the cost. You are paying for the science story and the bottle.

SerumProof score60 / 100
  • Evidence17 / 30

    Strength of the research behind the key actives

    • Growth Factors (TNS): moderate evidence
    • Trifluoroacetyl Tripeptide-2: limited evidence
    • Score is the average of the key actives’ evidence grades.
  • Potency20 / 25

    Dosed at studied levels, not fairy-dusted

    • Growth Factors (TNS): dosed at a studied level
    • Trifluoroacetyl Tripeptide-2: present, but below a studied dose
    • Potency tracks how strongly the actives are dosed, led by the strongest, not how many there are.
  • Delivery & stability16 / 20

    Delivery tech + packaging that protects fragile actives

    • Delivery: standard
    • Packaging: airless, opaque
    • Air- or light-sensitive actives (Growth Factors (TNS)), so packaging is scored.
  • Formulation4 / 10

    Disclosure, active breadth, and ingredient generation

    • 0 of 2 actives disclose a concentration
    • 2 key actives (breadth credit caps at 3)
    • Current-generation or synergistic: Growth Factors (TNS), Trifluoroacetyl Tripeptide-2
  • Value3 / 15

    What a month of use costs vs. the category

    • About $187 per month to use
    • $295 for 28.4 ml, used about twice a day (about 0.3 ml each time), so a bottle lasts about 1.6 months
    • Band: $6/month or less earns full marks, $60/month or more hits the floor.

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Where to buy at Sephora

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What’s inside

ActiveDisclosedDose
Growth Factors (TNS)n/aStudied
Trifluoroacetyl Tripeptide-2n/aLight

A prestige growth-factor serum built on Human Fibroblast Conditioned Media, plus whey peptides and a supporting peptide and antioxidant blend, in an airless, opaque, dual-chamber pump. The packaging protects its fragile proteins the way this category should. Levels are proprietary and not disclosed.

How it’s delivered

DeliveryStandardPackagingAirless, opaque

Air- and light-sensitive actives (vitamin C, copper peptides) lose potency fast in the wrong packaging, so delivery and the bottle are scored, not just what’s on the label.

The actives, explained

Cosmetic information for general education, not medical advice. The SerumProof score reflects our reading of publicly available research and formulation disclosures. See how scoring works.